:::

個人詳細資料

:::
˹ʹϤ
姓名 吳學亮
Office_Hour  
實驗室電話 (02)77346155
辦公室電話 (02)77346142
傳真 (02)29324249
聯絡地址 （11677）台北市文山區汀州路四段88號
E-mail hlw@ntnu.edu.tw
實驗室網頁  
類別 專任師資
職稱 副教授
研究領域 有機化學
不對稱合成
天然物合成
學術專長 有機化學
有機金屬化學
指導學生 博士後：Gopula Balraj 博士班：方若嫙 碩士班：簡嘉宏，曾昊葳，張瓊安，蔡蘊凡，周孟義，李韋賢，曾書皇，黃志浩，黃普航，江佩芬，王韻婷，林亞萱
實驗室 不對稱合成實驗室 /

學術著作

  1. 期刊論文
    1. Balraj Gopula, Chien-Wei Chiang, Way-Zen Lee, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Highly Enantioselective Rh-Catalyzed Asymmetric Alkenylation of Imines: Synthesis of Chiral Allylic Amines via Asymmetric Addition of Potassium Alkenyltrifluoroborates fo N-Tosyl Imines " Org. Lett. 2014, 16, 632-635.
    2. Chun-Chih Chen, Balraj Gopula, Jin-Fong Syu, Jhih-Han Pan, Ting-Shen Kuo, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Enantioselective and Rapid Rh-Catalyzed Arylation of N-Tosyl and N-Nosylaldimines in Methanol" J. Org. Chem. 2014, 79, 8077-8085.
    3. Kung-Chih Huang, Balraj Gopula, Ting-Shen Kuo, Chien-Wei Chiang, Ping-Yu Wu, Julian P. Henschke and Hsyueh-Liang Wu* " Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to β-Nitroolefins: Formal Synthesis of (S)-SKF 38393 " Org. Lett. 2013, 15, 5730-5733.
    4. Toshiyuki Moriuchi ,  Lisheng Mao ,  Hsyueh-Liang Wu ,  Satoshi D. Ohmura ,  Masami Watanabe and Toshikazu Hirao＊"Synthesis of facial cyclometalated iridium(III) complexes triggered by tripodal ligands" DALTON TRANSACTIONS , 2012, 41, 9519-9525.
    5. Balraj Gopula, Way-Zen Lee, and Hsyueh-Liang Wu* "Preparation of Chiral alpha-Substituted Alaninates through an Efficient Diastereoselective Synthesis of Trisubstituted Allylic Alcohols" Chem. Asian J. 2013, 8, 80-83. -Most Accessed from Jan/2013-Sep/2013
    6.  Ying-Ni Cheng, Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang* “Enantioselective Addition of Dialkylzincs to Aldehydes Catalyzed by (-)-MITH“ Chem. Asian. J. 2012, 7, 2921-2924.
    7. Yu-Chiang, Chung, Damodar Janmanchi and Hsyueh-Liang Wu* " Preparation of Chiral 3-Aryl Pyrrolidines via the Enantioselective 1,4-Addition of Arylboronic Acids to Fumaric Esters Catalyzed by Rh(I)/Chiral Diene Complexes." Org. Lett. 2012, 14, 2766-2769. 
    8. Chia-Chen Liu, Damodar Janmanchi, Chun-Chih Chen, Hsyueh-Liang Wu* “Expanding C1-Symmetric Bicyclo[2.2.1]heptadiene Ligand Family: Highly Enantioselective Synthesis of Cyclic b-Aryl Substituted Carbonyl Compounds.” Eur. J. Org. Chem. 2012, 2503-2507. 
    9. Wei-Ting Wei, Jiann-Yih Yeh, Ting-Shen Kuo, Hsyueh-Liang Wu* "Highly Enantioselective Rhodium-Catalyzed Asymmetric 1,4-Addition Reactions of Arylboronic Acids to Acyclic a,b-Unsaturated Compounds: The Formal Synthesis of (-)-Indatraline" Chem. Eur. J. 2011, 17, 11405-11409. 
    10. Ping-Yu Wu, Hsyueh-Liang Wu, Ying-Ying Shen, Biing-Jiun Uang “Asymmetric Synthesis of Propargylic Alcohols Catalyzed by (-)-MITH” Tetrahedron: Asymmetry 2009, 20, 1837-1841. 
    11. Zhi-Long Wu, Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “Asymmetric Addition of Diethylzinc to Aldehydes Catalyzed by a Camphor-Derived β-Amino Alcohol” Tetrahedron: Asymmetry 2009, 20, 1556-1560.
    12. Hsyueh-Liang Wu, Ping-Yu Wu, Biing-Jiun Uang “ Asymmetric Addition of Dimethylzinc to α-Ketoesters Catalyzed by (-)-MITH.” J. Org. Chem. 2008, 73, 6445-6447.
    13. Mei-Chi Chang, Hsyueh-Liang Wu, Chiu-Po Chan, Biing-Jiun Uang, Chia-Shan Lee, Bor-Dong Chen, Bor-Ru Lin, Hsiao-Hwa Chang, Chen-Jie Kao, Jiiang-Huei Jeng “Antithrombotic Effect of Hydroxychavicol, a Novel Betel Leaf Component: Role of Cyclooxygenase, Reactive Oxygen Species and Calcium Mobilization” British Journal of Pharmacology 2007, 152, 73-82. 
    14. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “ Highly enantioselective synthesis of (E)-allylic alcohols” J. Org. Chem. 2007, 72, 5935-5937 
    15. Toru Amaya, Koichi Mori, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Narkamura, Kazuhiko Murata, Toshikazu Hirao. “Synthesis and Characterization of π-extended Bowl-shaped π-Conjugated Molecules.” Chem. Commun. 2007, 1902-1904. 
    16. Ping-Yu Wu, Hsyueh-Liang Wu, and Biing-Jiun Uang, “Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol.” J. Org. Chem. 2006, 71, 833-835.
    17. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang (b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang 
    18. J. H. Jeng,Y. J. Wang, W. H. Chang, H. L. Wu, C. H. Li, B. J. Uang, J. J. Kang, J. J. Lee, L. J. Hahn, B. R. Lin, and M. C. Chang "Reactive Oxygen Species are Crucial for Hydroxychavicol Toxicity Toward KB Epithelial Cells" Cellular and Molecular Life Sciences, 2004, 61, 83-96.
    19. Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric Epoxidation of Allylic Alcohols Catalyzed by New Chiral Vanadium (V) Complexes”. Tetrahedron: Asymmetry 2002, 13, 2625.
    20. M. C. Chang, B. J. Uang. H. L. Wu, J. J. Lee, L. J. Hahn, J. H. Jeng. “Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol : roles of glutathione and reactive oxygen species” British Journal of Pharmacology 2002, 135, 619.
  2. 專書中之論文
    1. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang. A review article regarding “(-)-2-exo-Morpholinoisobornane-10-thiol” in e-EROS Encyclopedia of Reagents for Organic Synthesis. 
    2. Hsyueh-Liang Wu and Toshikazu Hirao. First update on “Vanadyl Bis(acetyl acetonate)” in e-EROS Encyclopedia of Reagents for Organic Synthesis. 
  3. 研討會論文
    1. I.  ORAL PRESENTATION
      1. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
      2. 1st Workshop on Organic Chemistry for Junior Chemists 2003 (NTHU-Nagaoka Institute of Technology) Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes catalyzed by camphor derived chiral ligands.”
      3. 4th Workshop on Organic Chemistry for Junior Chemists (2004), Tokyo Institute of Technology, Yokohama, Japan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor-Derived Ligands.
      4. NTHU-KAIST 2005 Junior Chemists Workshop (2005), National Tsing Hua University, Hsinchu, Taiwan. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang, (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes
      5. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes.
      6. 86th spring meeting. Toru Amaya, Hsyueh-Liang Wu, Satoshi Ishida, Jun-ichi Nakamura, Kazuhiko Murata, Hidehiro Sakurai, Toshikazu Hirao, Study on π- Conjugation of Bowl-shaped π-Conjugated Sumanene.
      7.International Symposium on Organic Reaction 2006. Toru Amaya, Hsyueh-Liang Wu, Koichi Mori, Toshikazu Hirao. Synthesis of p-conjugated Sumanenes
      8. Invited speaker in COEIEC 8 Symposium. Title: Camphor derived chiral ligands in organozincs addition to aldehydes.
      9. Invited speaker in WOCJC-7 Symposium. Title: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
      II. POSTER:
      1. 5th International Conference on Cutting Edge Organic Chemistry in Asia, Nov 7-11, 2010, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: Chiral [2.2.1] Diene Ligands for Asymmetric Catalysis
      2. 5th Workshop on Organic Chemistry for Junior Chemists. Nov 23-26, 2006, National Tsing Hua University, Hsinchu, Taiwan Presentation Titles: Asymmetric Catalytic Organozinc Addition Reactions Based on Camphor Derived Ligand. Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang.
      3. Post-Conference of 1st International Conference on Cutting Edge Organic Chemistry in Asia, Oct 21-24, 2006, National Tsing Hua University, Hsinchu, Taiwan, Presentation Titles: (a) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ−Amino Thiol (Best Poster Award) Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
      (b) The Effects of Sulfur and Oxygen Atoms of the Ligands in the Addition Reaction of Dialkylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      4. The 8th International 21st Century COE Symposium on Integrated EcoChemistry, Aug 28-29, 2006, Osaka University, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol
      Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
      5. The 8th International Symposium on Organic Reactions, Apr 23-26, 2006, Kobe,Japan. Presentation Titles: Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by γ-Amino Thiol Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      6. The 10th International Chemical Conference, Taipei, Oct 28-30, 2005, National Tsing Hua University, Hsinchu, Taiwan. Presentation Titles: (a) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH
      Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      (b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
      7. Tokyo Summer School on Frontier Chemistry 2005, Aug 25-27, 2005, The University of Tokyo, Tokyo, Japan Presentation Title: Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by γ-Amino Thiol
      Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
      8. NTHU-KAIST 2005 Junior Chemists Workshop, Feb 25-27, 2005, National Tsing Hua University, Hsinchu, Taiwan Presentation Title: (+)-Nonlinear Effect in Asymmetric Addition of the Diethylzinc to Aldehydes Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      9. Annual Meeting of Chinese Chemical Society, Taipei, Nov 19-20, 2005, National Sun Yat-Sen University, Kaohsiung, Taiwan Presentation Titles:
      (a) Camphor-Derived Oxazolines in Asymmetic Addition of Et2Zn to Aldehydes Ming-Shau Yang, Hsyueh-Liang Wu, Ping-Yu Wu, Che-Chia Chen and Biing-Jiun Uang
      (b) Asymmetric Synthesis of Functionalized Diarylmethanols Catalyzed by a New γ- Amino Thiol Ping-Yu Wu, Hsyueh-Liang Wu and Biing-Jiun Uang
      (c) Highly Enantioselective Addition of Alkenylzinc to Aldehydes Catalyzed by (-)- MITH Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      10. 4th Workshop on Organic Chemistry for Junior Chemists, Sep 24-27, 2004, Tokyo Institute of Technology, Japan Presentation Title: Enantioselective Addition of Diethylzinc Reagent to Aldehydes with Camphor Derived Ligands
      Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang
      11. Annual Symposium of Chinese Chemical Society 2004 a) Chih-Lung Wu, Hsyueh-Liang Wu and Biing-Jiun Uang “Enantioselective Addition of Et2Zn to Aldehydes Catalyzed by b-Amino Alcohols”.....ORS-B-089
      b) Hsyueh-Liang Wu, Ping-Yu Wu and Biing Jiun Uang “ (+)-Nonlinear Effect in Asymmetric Addition of the Et2Zn to Aldehydes.” ........ ORS-B-090.
      12. 3rd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2004 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes with camphor derived chiral ligands.”
      13. Annual Symposium of Chinese Chemical Society 2003 Hsyueh-Liang Wu, Ping-Yu Wu and Biing-Jiun Uang “Enantioselective addition of Et2Zn to aldehydes “..............................OR-PA-061.
      14.The 7th International Symposium for Chinese Organic Chemists 2002 Hsyueh- Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-058.
      15. Annual Symposium of Chinese Chemical Society 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Chiral camphor based hydroxamic acid catalyzed asymmetric epoxidation of allylic alcohols”........P-OR-072.
      16. 2nd Workshop on Organic Chemistry for Junior Chemists (TIT-NTHU) 2002 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
      17. 1st Workshop on Organic Chemistry for Junior Chemists 2002 (NTHU-Shanghai Institute of Organic Chemistry) Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.”
      18. 3rd International Symposium on Chemistry and Chemical Biology of Vanadium at Osaka Japan 2001 Hsyueh-Liang Wu and Biing-Jiun Uang “Asymmetric epoxidation of allylic alcohols catalyzed by camphor derived chiral hydroxamic acids.
  4. 專利
    1. 掌性雙烯配體及其製備方法與應用-中華民國專利申請中
研究計畫一覽
年度 計畫名稱 參與人 擔任之工作 計畫時間 補助/委託機構 附件檔案/參考連結 備註
102發展高效能過渡金屬催化不對稱反應並應用於合成具生理活性與藥性的分子吳學亮 2013年08月 ~
2015年07月		國科會  
100掌性雙環「2.2.1」雙烯配體在一價銠金屬催化之不對稱合成上的應用吳學亮主持人2011年08月 ~
2013年07月		國科會  
99具掌性四級碳之生理活性分子的合成：Sphingofungin F 的全合成吳學亮 2010年08月 ~
2012年07月		國科會  
98新型掌性雙烯配體的開發及其在不對稱合成上的應用吳學亮主持人2009年12月 ~
2010年07月		國科會  
經歷一覽
服務機關 職稱 部門/系所 擔任職務 起迄年月
大阪大學visiting professor supported by MEXT  2013年02月 ~ 2013年02月
國立臺灣師範大學副教授化學系 2013年02月 ~
大阪府立大學訪問教授化學系 2011年07月 ~ 2011年07月
國立臺灣師範大學助理教授化學系 2009年08月 ~ 2013年01月
美國麻省理工學院博士後研究  2008年07月 ~ 2009年06月
國立清華大學博士後研究  2007年04月 ~ 2008年06月
大阪大學博士後研究  2005年04月 ~ 2007年03月
國立清華大學博士後研究  2004年08月 ~ 2005年03月
學歷一覽
學校名稱 國別 系所 學位 起迄年月
國立清華大學臺灣化學所博士1998年09月 ~ 2004年06月
校外榮譽一覽
得獎年度 獎項名稱 頒獎單位
2013Asian Core Program Lectureship Award to Korea 
2013Asian Core Program Lectureship Award to Singapore 
2012Asian Core Program Lectureship Award to Japan 
web_use_log